Open AccessAntibody-suppressor CD8+ T Cells Require CXCR5
Author(s) -
Jason M. Zimmerer,
Bryce A Ringwald,
Steven M. Elzein,
Christina Avila,
Robert T Warren,
Mahmoud Abdel-Rasoul,
Ginny L. Bumgardner
Publication year - 2019
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002683
Subject(s) - cytotoxic t cell , cxcr3 , cd8 , cxcr5 , t cell , chemistry , interleukin 21 , microbiology and biotechnology , biology , immunology , antigen , antibody , b cell , in vitro , immune system , chemokine receptor , biochemistry , chemokine , germinal center
We previously reported the novel activity of alloprimed CD8 T cells that suppress posttransplant alloantibody production. The purpose of the study is to investigate the expression and role of CXCR5 on antibody-suppressor CD8 T-cell function.