Open AccessTwenty-year Follow-up of Histocompatibility Leukocyte Antigen-matched Kidney and Bone Marrow Cotransplantation for Multiple Myeloma With End-stage Renal Disease: Lessons Learned
Author(s) -
Thomas R. Spitzer,
Nina Tolkoff-Rubin,
A. Benedict Cosimi,
Steven L. McAfee,
Bimalangshu R. Dey,
Yi Bin Chen,
Francis L. Delmonico,
Megan Sykes,
David H. Sachs,
Tatsuo Kawai
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002669
Subject(s) - medicine , multiple myeloma , bone marrow , immunosuppression , histocompatibility , transplantation , immunology , end stage renal disease , kidney , antigen , human leukocyte antigen , disease
Specific immune tolerance of transplanted organs in association with either transient or sustained lymphohematopoietic chimerism has been demonstrated in several preclinical animal models and clinically in patients who are full donor chimeras after hematopoietic stem cell transplantation and subsequently received kidney transplants from the same donor. Most recently, tolerance induction has been extended to patients in whom chimerism was intentionally induced at the time of kidney transplantation.