Open AccessLaminin-511 Supplementation Enhances Stem Cell Localization With Suppression in the Decline of Cardiac Function in Acute Infarct Rats
Author(s) -
Nagako Sougawa,
Shigeru Miyagawa,
Satsuki Fukushima,
Junya Yokoyama,
Mutsunori Kitahara,
Akira Harada,
Noriko MochizukiOda,
Ryoko SatoNishiuchi,
Kiyotoshi Sekiguchi,
Yoshiki Sawa
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002653
Subject(s) - stem cell , mesenchymal stem cell , transplantation , extracellular matrix , angiogenesis , laminin , cd90 , microbiology and biotechnology , medicine , regeneration (biology) , fibronectin , pathology , immunology , biology , cd34
The extracellular matrix, in particular basement membrane components such as laminins (LMs), is essential for stem cell differentiation and self-renewal. LM511 and LM221 are the main extracellular matrix components of the epicardium, where stem cells were abundant. Here, we examined whether LMs affected the regeneration process by modulating stem cell activities.