Open AccessClinical Significance of Alloantibodies in Hand Transplantation: A Multicenter Study
Author(s) -
Erik Berglund,
Mette Andersen Ljungdahl,
Darko Bogdanović,
David Berglund,
Jonas Wadström,
Jan Kowalski,
Gerald Brandacher,
Dorota Kamińska,
Christina L. Kaufman,
Simon G. Talbot,
Kodi Azari,
Luis Landín,
C Höhnke,
Karen M. Dwyer,
Pedro C. Cavadas,
Alessandro Thioné,
Brendan Clarke,
Simon M. D. Kay,
Daniel Wilks,
Subramania Iyer,
Martín Iglesias,
Ömer Özkan,
Özlenen Özkan,
Johanna Krapf,
Annemarie Weißenbacher,
Palmina Petruzzo,
Stefan Schneeberger
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002650
Subject(s) - clinical significance , immunosuppression , medicine , transplantation , human leukocyte antigen , donor specific antibodies , antibody , correlation , isoantibodies , statistical significance , incidence (geometry) , immunology , stage (stratigraphy) , kidney transplantation , antigen , biology , geometry , mathematics , physics , optics , paleontology
Donor-specific antibodies (DSAs) have a strong negative correlation with long-term survival in solid organ transplantation. Although the clinical significance of DSA and antibody-mediated rejection (AMR) in upper extremity transplantation (UET) remains to be established, a growing number of single-center reports indicate their presence and potential clinical impact.