Open AccessHypothermic Oxygenated Machine Perfusion Alleviates Donation After Circulatory Death Liver Injury Through Regulating P-selectin-dependent and -independent Pathways in Mice
Author(s) -
Xianpeng Zeng,
Minli Li,
Xiaoli Fan,
Shuai Xue,
Wenjin Liang,
Zehong Fang,
Cheng Zeng,
Lin Fan,
Yan Xiong,
Yanfeng Wang,
Qifa Ye
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002621
Subject(s) - oxidative stress , liver injury , machine perfusion , perfusion , apoptosis , medicine , endothelium , p selectin , viaspan , necrosis , immunology , ischemia , endocrinology , chemistry , biochemistry , liver transplantation , transplantation , platelet , platelet activation
Hypothermic oxygenated machine perfusion (HOPE) has been shown to improve the quality of liver donation after circulatory death (DCD) compared to cold storage (CS). However, the mechanism by which HOPE works is unclear. In this study, a mouse liver HOPE system was developed to characterize the role of P-selectin in the protective effect of HOPE on DCD livers.