Open AccessA Novel Preservation Solution Containing a JNK Inhibitory Peptide Efficiently Improves Islet Yield for Porcine Islet Isolation
Author(s) -
Hirofumi Noguchi,
Chika Miyagi-Shiohira,
Yoshiki Nakashima,
Nana Ebi,
Eri Hamada,
Yoshihito Tamaki,
Kazuho Kuwae,
Shinji Kitamura,
Naoya Kobayashi,
Issei Saitoh,
Masami Watanabe
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002555
Subject(s) - islet , viaspan , collagenase , transplantation , chemistry , balanced salt solution , pancreas , endocrinology , biochemistry , medicine , biology , diabetes mellitus , enzyme , organic chemistry
For islet transplantation, pancreas preservation in University of Wisconsin (UW) solution is associated with disadvantages, such as collagenase inhibition, resulting in poor islet yield and islets with poor viability. In this study, we evaluated a novel preservation solution, the extracellular-type c-Jun N-terminal kinase (JNK) inhibitor-containing (EJ) solution.