Open AccessHuman Atrial Natriuretic Peptide in Cold Storage of Donation After Circulatory Death Rat Livers: An Old but New Agent for Protecting Vascular Endothelia?
Author(s) -
Yermek Nigmet,
Koichiro Hata,
Ichiro Tamaki,
Yusuke Okamura,
Tatsuaki Tsuruyama,
Hidetaka Miyauchi,
Jiro Kusakabe,
Tetsuya Tajima,
Hirofumi Hirao,
Takumi Kubota,
Osamu Inamoto,
Junichi Yoshikawa,
Toru Goto,
Hirokazu Tanaka,
Shinji Üemoto
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002552
Subject(s) - cold storage , medicine , endocrinology , atrial natriuretic peptide , ex vivo , transplantation , viaspan , downregulation and upregulation , chemistry , biology , biochemistry , gene , horticulture , in vitro
Current critical shortage of donor organs has increased the use of donation after circulatory death (DCD) livers for transplantation, despite higher risk for primary nonfunction or ischemic cholangiopathy. Human atrial natriuretic peptide (hANP) is a cardiovascular hormone that possesses protective action to vascular endothelia. We aimed to clarify the therapeutic potential of hANP in cold storage of DCD livers.