Open AccessMechanisms of Injury in APOL1-associated Kidney Disease
Author(s) -
Lijun Ma,
Jasmin Divers,
Barry I. Freedman
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002509
Subject(s) - nephropathy , medicine , kidney transplantation , kidney disease , transplantation , kidney , disease , chronic allograft nephropathy , pathogenesis , bioinformatics , genotyping , biology , genotype , genetics , endocrinology , gene , diabetes mellitus
An improved understanding of the pathogenesis in apolipoprotein L1 (APOL1) gene-associated chronic kidney disease (CKD) arose from observations in kidney transplantation. APOL1 genotyping could soon improve the safety of living kidney donation in individuals with recent African ancestry and alter the allocation of deceased donor kidneys.