Open AccessDonor-specific Cell-free DNA as a Biomarker in Solid Organ Transplantation. A Systematic Review
Author(s) -
Simon Knight,
Adam M Thorne,
Maria Letizia Lo Faro
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002482
Subject(s) - medicine , biomarker , cell free fetal dna , prospective cohort study , transplantation , biopsy , retrospective cohort study , urinary system , organ transplantation , cohort study , oncology , pathology , surgery , intensive care medicine , pregnancy , fetus , biochemistry , chemistry , prenatal diagnosis , biology , genetics
There is increasing interest in the use of noninvasive biomarkers to reduce the risks posed by invasive biopsy for monitoring of solid organ transplants (SOTs). One such promising marker is the presence of donor-derived cell-free DNA (dd-cfDNA) in the urine or blood of transplant recipients.