Open AccessEffect of the Selective NLRP3 Inflammasome Inhibitor mcc950 on Transplantation Outcome in a Pig Liver Transplantation Model With Organs From Donors After Circulatory Death Preserved by Hypothermic Machine Perfusion
Author(s) -
Yang Yu,
Ying Cheng,
Qi Pan,
Yijie Zhang,
Degong Jia,
Yongfeng Liu
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002461
Subject(s) - machine perfusion , inflammasome , transplantation , perfusion , medicine , liver transplantation , cold storage , reperfusion injury , ischemia , anesthesia , gastroenterology , receptor , pharmacology , surgery , biology , horticulture
We investigated whether the outcome of organs from donors after circulatory death (DCD) can be improved by the addition of mcc950 to the perfusate of the hypothermic machine perfusion (HMP) system and intravenous mcc950 injection after transplantation in a pig liver transplantation model.