Open AccessTemporal Changes in the Impact of HLA Mismatching Among Pediatric Kidney Transplant Recipients
Author(s) -
Jessica M. Ruck,
Annette M. Jackson,
Allan B. Massie,
Dorry L. Segev,
Niraj M. Desai,
Jacqueline Garonzik-Wang
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002426
Subject(s) - human leukocyte antigen , panel reactive antibody , immunosuppression , hazard ratio , medicine , transplantation , matching (statistics) , propensity score matching , kidney transplantation , histocompatibility testing , immunology , antigen , confidence interval , pathology
Allocation for pediatric deceased-donor kidney transplantation (pDDKT) in the United States now de-emphasizes HLA matching to improve equality in access to transplantation, but other national systems still consider HLA matching due to concerns about graft survival. We hypothesized that the impact of HLA mismatching has decreased over time due to advances including improved immunosuppression.