Open AccessSafety of Islet Autotransplantation After Pancreatectomy for Adenocarcinoma
Author(s) -
François Renaud,
Mikaël Chetboun,
Julien Thévenet,
Nathalie Delalleau,
Valéry Gmyr,
Thomas Hübert,
Caroline Bonner,
Mathieu Messager,
Emmanuelle Leteurtre,
C. Mariette,
Julie Kerr–Conte,
Guillaume Piessen,
François Pattou
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002419
Subject(s) - autotransplantation , medicine , pancreatectomy , islet , pancreatic fistula , pancreatic cancer , syngenic , xenotransplantation , surgery , adenocarcinoma , urology , pancreas , transplantation , gastroenterology , cancer , insulin
Total pancreatectomy with intraportal islet autotransplantation (TPIAT) rather than partial pancreatectomy could represent a major shift in the management of patients with resectable pancreatic ductal adenocarcinoma (PDAC) when risks of postoperative pancreatic fistula are well identified. This approach provides a theoretical risk of tumor cell dissemination when islet cells are transplanted into the portal vein. Our objective was to explore the safety of TPIAT in PDAC in a mouse preclinical model of subcutaneous xenotransplantation of human cells isolated from pancreatic specimen during partial pancreatectomy performed for PDAC.