Open AccessCell Spray Transplantation of Adipose-derived Mesenchymal Stem Cell Recovers Ischemic Cardiomyopathy in a Porcine Model
Author(s) -
Daisuke Mori,
Shigeru Miyagawa,
Satoshi Yajima,
Shunsuke Saito,
Satsuki Fukushima,
Takayoshi Ueno,
Köichi Toda,
Kotoe Kawai,
Hayato Kurata,
Hiroyuki Nishida,
Kayako Isohashi,
Jun Hatazawa,
Yoshiki Sawa
Publication year - 2018
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002385
Subject(s) - mesenchymal stem cell , transplantation , medicine , adipose tissue , cell therapy , cardiac function curve , stem cell , cardiology , angiogenesis , ischemic cardiomyopathy , cardiomyopathy , pathology , heart failure , biology , ejection fraction , microbiology and biotechnology
Allogeneic adipose-derived mesenchymal stem cells (ADSC) are promising cell sources for cell therapy to treat ischemic cardiomyopathy (ICM). We hypothesized that ADSC transplantation via the new cell spray method may be a feasible, safe, and effective treatment for ICM.