Open AccessTransplantation of Human-induced Pluripotent Stem Cell-derived Cardiomyocytes Is Superior to Somatic Stem Cell Therapy for Restoring Cardiac Function and Oxygen Consumption in a Porcine Model of Myocardial Infarction
Author(s) -
Masaru Ishida,
Shigeru Miyagawa,
Atsuhiro Saito,
Satsuki Fukushima,
Akira Harada,
Emiko Ito,
Fumiya Ohashi,
Tadashi Watabe,
Jun Hatazawa,
Kiyotaka Matsuura,
Yoshiki Sawa
Publication year - 2019
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002384
Subject(s) - transplantation , ejection fraction , medicine , cardiac function curve , cardiology , myocyte , induced pluripotent stem cell , myocardial infarction , stem cell , mesenchymal stem cell , cell therapy , stem cell therapy , heart failure , pathology , chemistry , biology , microbiology and biotechnology , embryonic stem cell , biochemistry , gene
Somatic stem cell (SC) therapy can improve cardiac performance following ischemic injury. In this study, we investigated whether induced pluripotent SC-derived cardiomyocytes (iPS-CMs) are more effective than somatic SCs, such as skeletal myoblasts (SM) and mesenchymal (M)SCs, in promoting functional recovery upon transplantation in a porcine model of myocardial infarction.