Open AccessNo Evidence for Cross-reactivity of Virus-specific Antibodies With HLA Alloantigens
Author(s) -
Sebastiaan Heidt,
Mariet C.W. Feltkamp,
Gonca E. Karahan,
Caroline S. de Brouwer,
Janneke Langerak-Langerak,
Arend Mulder,
Frans H.J. Claas
Publication year - 2018
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002369
Subject(s) - virology , human leukocyte antigen , virus , antigen , antibody , biology , immunology , cross reactivity , cytomegalovirus , monoclonal antibody , parvovirus , heterologous , herpesviridae , viral disease , genetics , cross reactions , gene
Antibodies directed against HLA can develop through pregnancy, blood transfusions, or organ transplants. Anecdotal evidence suggests that virus-specific antibodies may have the capacity to cross-react with HLA, a phenomenon called heterologous immunity, which is well described for T-cell alloreactivity.