Open AccessUnderstanding the Correlation Between DSA, Complement Activation, and Antibody-Mediated Rejection in Heart Transplant Recipients
Author(s) -
Qiuheng Zhang,
Michelle J. Hickey,
Diana Drogalis-Kim,
Ying Zheng,
David W. Gjertson,
Martín Cadeiras,
T. Khuu,
A. Baas,
E.C. DePasquale,
Nancy Hal,
Gregory Perens,
Juan Alejos,
Daniel Cruz,
Ali Nsair,
Richard J. Shemin,
Murray Kwon,
Michael C. Fishbein,
A. Ardehali,
Mario C. Deng,
Elaine F. Reed
Publication year - 2018
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002333
Subject(s) - medicine , heart transplantation , donor specific antibodies , human leukocyte antigen , antibody , incidence (geometry) , transplantation , cardiology , clinical significance , gastroenterology , antigen , immunology , physics , optics
Donor-specific HLA antibodies (DSA) are associated with increased rates of rejection and of graft failure in cardiac transplantation. The goal of this study was to determine the association of preformed and posttransplant development of newly detected DSA (ndDSA) with antibody-mediated rejection (AMR) and characterize the clinical relevance of complement-activating DSA in heart allograft recipients.