Open AccessMacroporous Dual-compartment Hydrogels for Minimally Invasive Transplantation of Primary Human Hepatocytes
Author(s) -
Nailah M. Seale,
Suvasini Ramaswamy,
YuRu V. Shih,
Inder M. Verma,
Shyni Varghese
Publication year - 2018
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002330
Subject(s) - self healing hydrogels , compartment (ship) , transplantation , primary (astronomy) , dual (grammatical number) , chemistry , medicine , surgery , polymer chemistry , oceanography , geology , art , physics , literature , astronomy
Given the shortage of available organs for whole or partial liver transplantation, hepatocyte cell transplantation has long been considered a potential strategy to treat patients suffering from various liver diseases. Some of the earliest approaches that attempted to deliver hepatocytes via portal vein or spleen achieved little success due to poor engraftment. More recent efforts include transplantation of cell sheets or thin hepatocyte-laden synthetic hydrogels. However, these implants must remain sufficiently thin to ensure that nutrients can diffuse into the implant.