Open AccessDonor-derived Viral Infections in Liver Transplantation
Author(s) -
Hannah Nam,
Kathy M. Nilles,
Josh Levitsky,
Michael G. Ison
Publication year - 2018
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002326
Subject(s) - medicine , immunology , transplantation , serology , cytomegalovirus , transmission (telecommunications) , liver transplantation , virology , disease , epidemiology , antibody , viral disease , virus , herpesviridae , electrical engineering , engineering
Donor-derived infections are defined as any infection present in the donor that is transmitted to 1 or more recipients. Donor-derived infections can be categorized into 2 groups: "expected" and "unexpected" infections. Expected transmissions occur when the donor is known to have an infection, such as positive serology for cytomegalovirus, Epstein Barr virus, or hepatitis B core antibody, at the time of donation. Unexpected transmissions occur when a donor has no known infection before donation, but 1 or more transplant recipients develop an infection derived from the common donor. Unexpected infections are estimated to occur in far less than 1% of solid organ transplant recipients. We will review the epidemiology, risk factors, and approaches to prevention and management of donor-derived viral infectious disease transmission in liver transplantation.