Open AccessEarly TLR4 Blockade Attenuates Sterile Inflammation-mediated Stress in Islets During Isolation and Promotes Successful Transplant Outcomes
Author(s) -
Charles Chang,
Kayla L. Murphy,
Robert R. Kane,
Michael C. Lawrence,
Bashoo Naziruddin
Publication year - 2018
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002287
Subject(s) - tlr4 , islet , inflammation , blockade , medicine , transplantation , endocrinology , pancreatic islets , diabetes mellitus , immunology , pharmacology , receptor
During the isolation process, pancreatic islets are exposed to an environment of sterile inflammation resulting in an upregulated inflammatory state before transplantation. Toll-like receptor 4 (TLR4) has been identified as a major mediator of sterile inflammation. Therefore, we sought to determine whether early TLR4 blockade would be effective in reducing the inflammatory burden in islets pretransplant.