Open AccessDifferential Impact of T-bet and IFNγ on Pancreatic Islet Allograft Rejection
Author(s) -
Alix Besançon,
Zeynep Demir,
Tania Goncalves,
Fabrice Valette,
Emilie Panafieu,
Lucienne Chatenoud,
Sylvaine You
Publication year - 2018
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002261
Subject(s) - granzyme b , islet , cytotoxic t cell , cd8 , perforin , pancreatic islets , tumor necrosis factor alpha , biology , granzyme , immunology , cancer research , t cell , immune system , endocrinology , in vitro , diabetes mellitus , biochemistry
T cell-mediated graft rejection is mostly correlated with potent Th1 responses. However, because IFNγ mice reject their graft as efficiently as wild-type (WT) mice, the exact contribution of IFNγ and its transcription factor T-bet remains a matter of debate. Here, we address this question in the context of pancreatic islet allograft to better inform the molecular pathways that hampers islet survival in vivo.