Open AccessAdvances on CD8+ Treg Cells and Their Potential in Transplantation
Author(s) -
Séverine Bézie,
Ignacio Anegón,
Carole Guillonneau
Publication year - 2018
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002258
Subject(s) - foxp3 , transplantation , immunology , cd8 , medicine , immune tolerance , treg cell , cytotoxic t cell , immune system , biology , t cell , il 2 receptor , in vitro , genetics
Although cluster of differentiation (CD)8 regulatory T (Treg) cells have been in the last 20 years more studied since evidences of their role in tolerance as been demonstrated in transplantation, autoimmune diseases and cancer, their characteristics are still controversial. In this review, we will focus on recent advances on CD8 Treg cells and description of a role for CD8 Treg cells in tolerance in both solid organ transplantation and graft-versus-host disease and their potential for clinical trials.