Open AccessCaspase Inhibition During Cold Storage Improves Graft Function and Histology in a Murine Kidney Transplant Model
Author(s) -
Trevor L. Nydam,
Robert J. Plenter,
Swati Jain,
Scott Lucia,
Alkesh Jani
Publication year - 2018
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002218
Subject(s) - histology , kidney , cold storage , kidney transplant , kidney transplantation , medicine , pathology , biology , horticulture
Prolonged cold ischemia is a risk factor for delayed graft function of kidney transplants, and is associated with caspase-3-mediated apoptotic tubular cell death. We hypothesized that treatment of tubular cells and donor kidneys during cold storage with a caspase inhibitor before transplant would reduce tubular cell apoptosis and improve kidney function after transplant.