Open AccessCORM-401 Reduces Ischemia Reperfusion Injury in an Ex Vivo Renal Porcine Model of the Donation After Circulatory Death
Author(s) -
Rabindra N. Bhattacharjee,
Mahms Richard-Mohamed,
Qizhi Sun,
Aaron Haig,
Ghaleb Aboalsamh,
Peter A. Barrett,
Richard Mayer,
Ibrahim Alhasan,
Karen Pineda-Solís,
Larry Jiang,
Hajed O Alharbi,
Manujendra N. Saha,
Eric K. Patterson,
Alp Şener,
Gediminas Cepinskas,
Anthony M. Jevnikar,
Patrick Luke
Publication year - 2018
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000002201
Subject(s) - medicine , transplantation , kidney , reperfusion injury , ischemia , pathology , pharmacology
Carbon monoxide (CO) inhalation protects organ by reducing inflammation and cell death during transplantation processes in animal model. However, using CO in clinical transplantation is difficult due to its delivery in a controlled manner. A manganese-containing CO releasing molecules (CORM)-401 has recently been synthesized which can efficiently deliver 3 molar equivalents of CO. We report the ability of this anti-inflammatory CORM-401 to reduce ischemia reperfusion injury associated with prolonged cold storage of renal allografts obtained from donation after circulatory death in a porcine model of transplantation.