Open AccessThe Optimization of the Prevascularization Procedures for Improving Subcutaneous Islet Engraftment
Author(s) -
Satomi Uematsu,
Akiko Inagaki,
Yasuhiro Nakamura,
Takehiro Imura,
Yasuhiro Igarashi,
Ibrahim Fathi,
Shigehito Miyagi,
Noriaki Ohuchi,
Susumu Satoh,
Masafumi Goto
Publication year - 2018
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000001970
Subject(s) - islet , medicine , basic fibroblast growth factor , transplantation , subcutaneous injection , insulin , growth factor , receptor
Subcutaneous islet transplantation is associated with minimal invasiveness, but poor vascularization. Thus, the optimization of the prevascularization procedures is crucial for improving the outcomes. Although the effectiveness of basic fibroblast growth factor (bFGF) was reported, the optimal procedures remain unclear. We sought to optimize the prevascularization procedures including the use of a novel scaffold, recombinant peptide (RCP).