Open AccessThe Risk of Transplant Failure With HLA Mismatch in First Adult Kidney Allografts From Deceased Donors
Author(s) -
Robert C. Williams,
Gerhard Opelz,
Chelsea J. McGarvey,
E. Jennifer Weil,
Harini A. Chakkera
Publication year - 2016
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000001115
Subject(s) - hazard ratio , human leukocyte antigen , medicine , proportional hazards model , confidence interval , cohort , kidney transplantation , kidney , transplantation , immunology , antigen
Since the beginning of the technology, there has been active debate about the role of human leucocyte antigen (HLA) matching in kidney allograft survival. Recent studies have reported diminishing importance of HLA matching, which have, in turn, been challenged by reports that suggest the continuing importance of these loci. Given the controversies, we examined the effect of HLA compatibility on kidney allograft survival by studying all first adult kidney transplants in the United States from a deceased donor.