Open AccessAdvantages and pitfalls of combining intravenous antithrombin with nebulized heparin and tissue plasminogen activator in acute respiratory distress syndrome
Author(s) -
Sebastian Rehberg,
Yusuke Yamamoto,
Linda E. Sousse,
Collette Jonkam,
Robert A. Cox,
Donald S. Prough,
Perenlei Enkhbaatar
Publication year - 2014
Publication title -
the journal of trauma and acute care surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.25
H-Index - 187
eISSN - 2163-0763
pISSN - 2163-0755
DOI - 10.1097/ta.0b013e3182ab0785
Subject(s) - ards , medicine , anesthesia , saline , coagulopathy , antithrombin , tissue plasminogen activator , heparin , respiratory distress , lung , surgery
Pulmonary coagulopathy has become an important therapeutic target in adult respiratory distress syndrome (ARDS). We hypothesized that combining intravenous recombinant human antithrombin (rhAT), nebulized heparin, and nebulized tissue plasminogen activator (TPA) more effectively improves pulmonary gas exchange compared with a single rhAT infusion, while maintaining the anti-inflammatory properties of rhAT in ARDS. Therefore, the present prospective, randomized experiment was conducted using an established ovine model.