Open AccessAssociation of trauma severity with antibody seroconversion in heparin-induced thrombocytopenia: A multicenter, prospective, observational study
Author(s) -
Motoo Fujita,
Takuma Maeda,
Shigeki Miyata,
Asumi Mizugaki,
Mineji Hayakawa,
Noriko Miyagawa,
Noritaka Ushio,
Atsushi Shiraishi,
Takayuki Ogura,
Shiho Irino,
Keitaro Sekine,
Yoshihisa Fujinami,
Kazutaka Kiridume,
Toru Hifumi,
Shigeki Kushimoto
Publication year - 2022
Publication title -
the journal of trauma and acute care surgery
Language(s) - English
Resource type - Journals
eISSN - 2163-0763
pISSN - 2163-0755
DOI - 10.1097/ta.0000000000003603
Subject(s) - seroconversion , medicine , heparin induced thrombocytopenia , heparin , platelet factor 4 , prospective cohort study , observational study , antibody , injury severity score , platelet , gastroenterology , immunology , poison control , emergency medicine , injury prevention
Heparin administration can induce the production of anti-platelet factor 4 (PF4)/heparin antibodies with platelet-activating properties, causing heparin-induced thrombocytopenia (HIT). Previous studies have suggested that trauma severity influences HIT immune responses, but their relationship has not been fully explained. This study aimed to clarify this association by multicenter prospective observational study.