Open AccessA new trauma frontier: Exploratory pilot study of platelet transcriptomics in trauma patients
Author(s) -
Alexander T. Fields,
Man-Cheung Lee,
Fahima Mayer,
Yale Santos,
Cedric M.V. Bainton,
Zachary A. Matthay,
Rachael A. Callcut,
Nasima Mayer,
Joseph Cuschieri,
Kord M. Kober,
Roland J. Bainton,
Lucy Z. Kornblith
Publication year - 2021
Publication title -
the journal of trauma and acute care surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.25
H-Index - 187
eISSN - 2163-0763
pISSN - 2163-0755
DOI - 10.1097/ta.0000000000003450
Subject(s) - transcriptome , platelet , rna splicing , alternative splicing , biology , gene , platelet activation , gene expression , rna , messenger rna , bioinformatics , immunology , genetics
The earliest measurable changes to postinjury platelet biology may be in the platelet transcriptome, as platelets are known to carry messenger ribonucleic acids (RNAs), and there is evidence in other inflammatory and infectious disease states of differential and alternative platelet RNA splicing in response to changing physiology. Thus, the aim of this exploratory pilot study was to examine the platelet transcriptome and platelet RNA splicing signatures in trauma patients compared with healthy donors.