Open AccessExtrathoracic multiple trauma dysregulates neutrophil function and exacerbates pneumonia-induced lung injury
Author(s) -
Jennifer Leonard,
Christina X. Zhang,
Liang Lü,
Mark H. Hoofnagle,
Anja Fuchs,
Regina A. Clemens,
Subham Ghosh,
Shin-Wen Hughes,
Grant V. Bochicchio,
Richard Hotchkiss,
Isaiah R. Turnbull
Publication year - 2021
Publication title -
the journal of trauma and acute care surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.25
H-Index - 187
eISSN - 2163-0763
pISSN - 2163-0755
DOI - 10.1097/ta.0000000000003147
Subject(s) - medicine , pneumonia , lung function , lung , intensive care medicine
Forty percent of critically ill trauma patients will develop an infectious complication. Pneumonia is the most common cause of death of trauma patients surviving their initial insult. We previously demonstrated that polytrauma (PT), defined as two or more severe injuries in at least two areas of the body, induces emergency hematopoiesis characterized by accelerated myelopoiesis in the bone marrow and increased myeloid cell frequency in the peripheral tissues. We hypothesized that PT alone induces priming of neutrophils, resulting in hyperactivation upon secondary exposure to bacteria and causing acute lung injury and increased susceptibility to secondary exposure to Pseudomonas aeruginosa pneumonia.