Open AccessAntithrombin III ameliorates post–traumatic brain injury cerebral leukocyte mobilization enhancing recovery of blood brain barrier integrity
Author(s) -
Mohamed ElSaadani,
Syed Ahmed,
Christina L. Jacovides,
Alfonso J Lopez,
Victoria E. Johnson,
Lewis J. Kaplan,
C. William Schwab,
Douglas H. Smith,
José L. Pascual
Publication year - 2020
Publication title -
the journal of trauma and acute care surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.25
H-Index - 187
eISSN - 2163-0763
pISSN - 2163-0755
DOI - 10.1097/ta.0000000000003000
Subject(s) - traumatic brain injury , antithrombin , blood–brain barrier , medicine , anesthesia , morris water navigation task , pharmacology , heparin , central nervous system , hippocampal formation , psychiatry
Acute traumatic coagulopathy often accompanies traumatic brain injury (TBI) and may impair cognitive recovery. Antithrombin III (AT-III) reduces the hypercoagulability of TBI. Antithrombin III and heparinoids such as enoxaparin (ENX) demonstrate potent anti-inflammatory activity, reducing organ injury and modulating leukocyte (LEU) activation, independent of their anticoagulant effect. It is unknown what impact AT-III exerts on cerebral LEU activation and blood-brain barrier (BBB) permeability after TBI. We hypothesized that AT-III reduces live microcirculatory LEU-endothelial cell (EC) interactions and leakage at the BBB following TBI.