Open AccessHepatic inflammation after burn injury is associated with necroptotic cell death signaling
Author(s) -
Juan Pablo Idrovo,
Devin M. Boe,
Soncy Kaahui,
Weng Lang Yang,
Elizabeth J. Kovacs
Publication year - 2020
Publication title -
the journal of trauma and acute care surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.25
H-Index - 187
eISSN - 2163-0763
pISSN - 2163-0755
DOI - 10.1097/ta.0000000000002865
Subject(s) - necroptosis , burn injury , inflammation , liver injury , medicine , tumor necrosis factor alpha , pathology , biology , programmed cell death , endocrinology , immunology , apoptosis , surgery , biochemistry
Burn injury still has a high attributable mortality. The elevated mortality rate of severe burns is still concerning. Hepatic inflammation and injury are common after burns and are associated with poor outcomes. Necroptosis is a programmed cell death linked with inflammation. Thus, assessing necroptotic pathways in the liver can lead to new therapeutic modalities to improve mortality after severe burns.