Open AccessHuman neural stem cell transplant location–dependent neuroprotection and motor deficit amelioration in rats with penetrating traumatic brain injury
Author(s) -
Zhen Hu,
Shyam Gajavelli,
Markus Spurlock,
Anil Mahavadi,
Liz S Quesada,
Ganesh R Gajavelli,
Cody B Andreoni,
Long Di,
Julia Janecki,
Stephanie W Lee,
Karla N. Rivera,
Deborah A. Shear,
Ross Bullock
Publication year - 2019
Publication title -
the journal of trauma and acute care surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.25
H-Index - 187
eISSN - 2163-0763
pISSN - 2163-0755
DOI - 10.1097/ta.0000000000002510
Subject(s) - traumatic brain injury , lesion , neuroprotection , neural stem cell , medicine , transplantation , cortex (anatomy) , neurogenesis , stem cell , pathology , surgery , neuroscience , biology , psychiatry , genetics
Penetrating traumatic brain injury induces chronic inflammation that drives persistent tissue loss long after injury. Absence of endogenous reparative neurogenesis and effective neuroprotective therapies render injury-induced disability an unmet need. Cell replacement via neural stem cell transplantation could potentially rebuild the tissue and alleviate penetrating traumatic brain injury disability. The optimal transplant location remains to be determined.