Open AccessValproic acid improves survival and decreases resuscitation requirements in a swine model of prolonged damage control resuscitation
Author(s) -
Aaron M. Williams,
Umar F. Bhatti,
Ben E. Biesterveld,
Nathan J. Graham,
Kiril Chtraklin,
Jing Zhou,
Isabel S. Dennahy,
Ranganath G Kathawate,
Claire A. Vercruysse,
Rachel M. Russo,
Yongqing Li,
Hasan B. Alam
Publication year - 2019
Publication title -
the journal of trauma and acute care surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.25
H-Index - 187
eISSN - 2163-0763
pISSN - 2163-0755
DOI - 10.1097/ta.0000000000002281
Subject(s) - resuscitation , medicine , valproic acid , shock (circulatory) , anesthesia , hemodynamics , blood transfusion , blood pressure , surgery , psychiatry , epilepsy
Although damage control resuscitation (DCR) is routinely performed for short durations, prolonged DCR may be required in military conflicts as a component of prolonged field care. Valproic acid (VPA) has been shown to have beneficial properties in lethal hemorrhage/trauma models. We sought to investigate whether the addition of a single dose of VPA to a 72-hour prolonged DCR protocol would improve clinical outcomes.