Open AccessEarly heparin administration after traumatic brain injury
Author(s) -
Katsuhiro Nagata,
Kevin D. Browne,
Yujin Suto,
Kenichiro Kumasaka,
John S. Cognetti,
Victoria E. Johnson,
Joshua A. Marks,
Douglas H. Smith,
José L. Pascual
Publication year - 2017
Publication title -
the journal of trauma and acute care surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.25
H-Index - 187
eISSN - 2163-0763
pISSN - 2163-0755
DOI - 10.1097/ta.0000000000001590
Subject(s) - traumatic brain injury , medicine , anesthesia , psychiatry
Early administration of unfractionated heparin (UFH) after traumatic brain injury (TBI) reduces early in vivo circulating leukocytes (LEUs) in peri-injury penumbral brain tissue, enhancing cognitive recovery 2 days after injury. It remains unclear how long this effect lasts and if this is related to persistently accumulating LEUs in penumbral brain tissue. We hypothesized that UFH reduces LEU brain tissue sequestration resulting in prolonged cognitive recovery.