Open AccessRecovery of fibrinogen concentrate after intraosseous application is equivalent to the intravenous route in a porcine model of hemodilution
Author(s) -
Christoph J. Schlimp,
Cristina Solomon,
Claudia Keibl,
Johannes Zipperle,
Sylvia Nürnberger,
W. Öhlinger,
Heinz Redl,
Herbert Schöchl
Publication year - 2014
Publication title -
the journal of trauma and acute care surgery
Language(s) - English
Resource type - Journals
eISSN - 2163-0763
pISSN - 2163-0755
DOI - 10.1097/ta.0000000000000174
Subject(s) - fibrinogen , medicine , thromboelastometry , partial thromboplastin time , anesthesia , prothrombin time , coagulation , thromboplastin , surgery , coagulation testing
Fibrinogen concentrate is increasingly considered as a hemostatic agent for trauma patients experiencing bleeding. Placing a venous access is sometimes challenging during severe hemorrhage. Intraosseous access may be considered instead. Studies of intraosseous infusion of coagulation factor concentrates are limited. We investigated in vivo recovery following intraosseous administration of fibrinogen concentrate and compared the results with intravenous administration.