Open AccessInhibition of Bruton’s Tyrosine Kinase Activity Attenuates Hemorrhagic Shock-Induced Multiple Organ Dysfunction in Rats
Author(s) -
Nikita M Patel,
Filipe R M B Oliveira,
Hanna Pillmann Ramos,
Eleonora Aimaretti,
Gustavo Ferreira Alves,
Sina M. Coldewey,
Massimo Collino,
Regina Sordi,
Christoph Thiemermann
Publication year - 2021
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/sla.0000000000005357
Subject(s) - medicine , bruton's tyrosine kinase , shock (circulatory) , hemorrhagic shock , organ dysfunction , tyrosine kinase , endocrinology , receptor , sepsis
The aim of this study was to investigate (a) the potential of the Bruton's tyrosine kinase (BTK) inhibitors acalabrutinib and fenebrutinib to reduce multiple organ dysfunction syndrome (MODS) in acute (short-term and long-term follow-up) hemorrhagic shock (HS) rat models and (b) whether treatment with either acalabrutinib or fenebrutinib attenuates BTK, NF-κB and NLRP3 activation in HS.