Open AccessPrevention of Anastomotic Leak Via Local Application of Tranexamic Acid to Target Bacterial-mediated Plasminogen Activation
Author(s) -
Richard A. Jacobson,
Ashley J. Williamson,
Kiedo Wienholts,
Sara Gaines,
Sanjiv Hyoju,
Harry van Goor,
Alexander Zaborin,
Benjamin D. Shogan,
Olga Zaborina,
John C. Alverdy
Publication year - 2019
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/sla.0000000000003733
Subject(s) - medicine , tranexamic acid , anastomosis , leak , surgery , blood loss , environmental engineering , engineering
To investigate the role of bacterial- mediated plasminogen (PLG) activation in the pathogenesis of anastomotic leak (AL) and its mitigation by tranexamic acid (TXA).