Open AccessCytoplasmic Cyclin E Expression Predicts for Response to Neoadjuvant Chemotherapy in Breast Cancer
Author(s) -
Cansu Karakaş,
Ashleigh M. Francis,
Min Jin Ha,
Hannah Wingate,
Richard A. Meena,
Min Yi,
Komal S. Rasaputra,
Angelica Gutierrez Barrera,
Banu K. Arun,
Kim Anh,
Ayşegül Şahin,
Khandan Keyomarsi,
Kelly K. Hunt
Publication year - 2019
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/sla.0000000000003551
Subject(s) - medicine , breast cancer , chemotherapy , oncology , neoadjuvant therapy , immunohistochemistry , cancer , cyclin e , cyclin d1 , pathology , cell cycle
Pathologic complete response (pCR) has been shown to be associated with favorable outcomes in breast cancer. Predictors of pCR could be useful in guiding treatment decisions regarding neoadjuvant therapy. The objective of this study was to evaluate cyclin E as a predictor of response to neoadjuvant chemotherapy in breast cancer.