Open AccessTargeting the Hedgehog Pathway Using Itraconazole to Prevent Progression of Barrett's Esophagus to Invasive Esophageal Adenocarcinoma
Author(s) -
Ronan J. Kelly,
Amir Ansari,
Tomoharu Miyashita,
Marianna Zahurak,
Frank Lay,
Ali Ahmed,
Louis J. Born,
Maryam Kherad Pezhouh,
Kevan J. Salimian,
Christopher Ng,
Aerielle E. Matsangos,
Anne Heloise Stricker-Krongrad,
Ken Ichi Mukaisho,
Guy Marti,
Christine H. Chung,
Marcia Irene Canto,
Michelle A. Rudek,
Stephen J. Meltzer,
John W. Harmon
Publication year - 2019
Publication title -
annals of surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.153
H-Index - 309
eISSN - 1528-1140
pISSN - 0003-4932
DOI - 10.1097/sla.0000000000003455
Subject(s) - medicine , hedgehog signaling pathway , itraconazole , esophagus , gastroenterology , barrett's esophagus , adenocarcinoma , urology , oncology , pathology , cancer , dermatology , biology , signal transduction , antifungal , biochemistry
The aim of the study was to investigate whether inhibition of Sonic Hedgehog (SHH) pathway would prevent progression of Barrett's Esophagus (BE) to esophageal adenocarcinoma.