Open AccessRedox Potential Correlates with Changes in Metabolite Concentrations Attributable to Pathways Active in Oxidative Stress Response in Swine Traumatic Shock
Author(s) -
Rodney C. Daniels,
Mohamad Hakam Tiba,
Brandon C Cummings,
Yan Rou Yap,
Sardar Ansari,
Brendan McCracken,
Yihan Sun,
Theodore S. Jennaro,
Kevin R. Ward,
Kathleen A. Stringer
Publication year - 2022
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001944
Subject(s) - metabolite , oxidative stress , chemistry , metabolomics , urine , redox , active metabolite , pharmacology , shock (circulatory) , biochemistry , medicine , chromatography , organic chemistry
Oxidation-reduction (redox) reactions, and the redox potential (RP) that must be maintained for proper cell function, lie at the heart of physiologic processes in critical illness. Imbalance in RP reflects systemic oxidative stress, and whole blood RP measures have been shown to correlate with oxygen debt level over time in swine traumatic shock. We hypothesize that RP measures reflect changing concentrations of metabolites involved in oxidative stress. To test this hypothesis, we compared blood and urine RP with concentrations of multiple metabolites in a swine traumatic shock model to identify meaningful RP-metabolite relationships.