Open AccessShock-Induced Endothelial Dysfunction is Present in Patients With Occult Hypoperfusion After Trauma
Author(s) -
Heather R. Kregel,
Gabrielle E Hatton,
Kayla D. Isbell,
H Henriksen,
Jakob Stensballe,
Pär I. Johansson,
Lillian S. Kao,
Charles E. Wade
Publication year - 2021
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001866
Subject(s) - medicine , perfusion , shock (circulatory) , endothelial dysfunction , trauma center , cardiology , blood pressure , endothelium , gastroenterology , endocrinology , retrospective cohort study
Shock-induced endothelial dysfunction, evidenced by elevated soluble thrombomodulin (sTM) and syndecan-1 (Syn-1), is associated with poor outcomes after trauma. The association of endothelial dysfunction and overt shock has been demonstrated; it is unknown if hypoperfusion in the setting of normal vital signs (occult hypoperfusion [OH]) is associated with endothelial dysfunction. We hypothesized that sTM and Syn-1 would be elevated in patients with OH when compared to patients with normal perfusion.