Open AccessElevated Plasma Levels of Matrix Metalloproteinase-3 and Tissue-Inhibitor of Matrix Metalloproteinases-1 Associate With Organ Dysfunction and Mortality in Sepsis
Author(s) -
T.K. Jones,
John P. Reilly,
Brian J. Anderson,
Todd Miano,
Thomas Dunn,
A.R. Weisman,
R.S. Agyekum,
Rui Feng,
C.A.G. Ittner,
Michael G. S. Shashaty,
Nuala J. Meyer
Publication year - 2021
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001833
Subject(s) - ards , medicine , sepsis , matrix metalloproteinase , odds ratio , organ dysfunction , shock (circulatory) , intensive care unit , gastroenterology , prospective cohort study , acute kidney injury , septic shock , lung
Matrix Metalloproteinases (MMP) respond to tissue damage during sepsis. Higher plasma concentrations of MMPs and the tissue-inhibitor of matrix metalloproteinases (TIMP) have been reported in sepsis compared with healthy controls. The objective of this study was to examine if plasma levels of MMP-3, MMP-9, and TIMP-1 associate with mortality and organ dysfunction during sepsis.