Open AccessDirect Airway Instillation of Neutrophils Overcomes Chemotactic Deficits Induced by Injury
Author(s) -
QuanZhi Zhang,
Woon Yong Kwon,
Barbora Vlková,
Ingred Riça,
Elżbieta Kaczmarek,
Jin Bong Park,
Hyo In Kim,
Barbora Konečná,
Françoise Jung,
Garry J. Douglas,
Leo E. Otterbein,
Carl J. Hauser,
Kiyoshi Itagaki
Publication year - 2020
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001691
Subject(s) - chemotaxis , pneumonia , lung , immunology , receptor , staphylococcus aureus , airway , neutrophile , medicine , chemistry , inflammation , biology , bacteria , anesthesia , genetics
Trauma induces neutrophil migration toward injury sites, both initiating wound healing and protecting against local bacterial infection. We have previously shown that mitochondrial formyl peptides (mtFPs) released by injured tissues act as chemoattractants by ligating neutrophil (PMN) formyl peptide receptor 1 (FPR1). But this process can also internalize multiple neutrophil chemoattractant receptors and thus might limit neutrophil migration to the lung in response to bacteria. Our objective was to better understand susceptibility to pneumonia after injury and thus find ways to reverse it.