Open AccessThrombin Generation Kinetics are Predictive of Rapid Transfusion in Trauma Patients Meeting Critical Administration Threshold
Author(s) -
Taleen A. MacArthur,
Grant M. Spears,
Rosemary A. Kozar,
Jing Dong,
Matthew Auton,
Donald H. Jenkins,
Kent R. Bailey,
Aneel A. Ashrani,
Mike J. Ferrara,
Joseph M. Immermann,
Timothy Halling,
Myung S. Park
Publication year - 2020
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001633
Subject(s) - medicine , confidence interval , logistic regression , odds ratio , thrombin generation , injury severity score , prothrombin time , shock (circulatory) , packed red blood cells , prospective cohort study , blood transfusion , anesthesia , platelet , surgery , thrombin , emergency medicine , poison control , injury prevention
We hypothesize that a patient (pt) with accelerated thrombin generation, time to peak height (ttPeak), will have a greater odds of meeting critical administration threshold (CAT) criteria (> 3 packed red blood cell [pRBC] transfusions [Tx] per 60 min interval), within the first 24 h after injury, independent of international normalized ratio (INR).