Open AccessOverexpressed lncRNA AC068039.4 Contributes to Proliferation and Cell Cycle Progression of Pulmonary Artery Smooth Muscle Cells Via Sponging miR-26a-5p/TRPC6 in Hypoxic Pulmonary Arterial Hypertension
Author(s) -
Qin Yuhan,
Bingqian Zhu,
Li Linqing,
Dong Wang,
Qiao Ye,
Bo Liu,
Erfei Luo,
Jiantong Hou,
Gaoliang Yan,
Chengchun Tang
Publication year - 2020
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001606
Subject(s) - cell cycle , pulmonary hypertension , western blot , downregulation and upregulation , hypoxia (environmental) , cell growth , cancer research , pulmonary artery , microrna , microarray analysis techniques , biology , flow cytometry , microbiology and biotechnology , cell , chemistry , medicine , gene expression , gene , biochemistry , oxygen , genetics , organic chemistry
Hypoxic pulmonary hypertension (HPH) is a devastating and incurable disease characterized by pulmonary vascular remodeling, resulting in right heart failure and even death. Accumulated evidence has confirmed long coding RNAs (lncRNAs) are involved in hypoxia-induced pulmonary vascular remodeling in HPH. The exact mechanism of lncRNA in hypoxic pulmonary hypertension remains unclear.