Open AccessModulation of Brain Transcriptome by Combined Histone Deacetylase Inhibition and Plasma Treatment Following Traumatic Brain Injury and Hemorrhagic Shock
Author(s) -
Simone E. Dekker,
Ben E. Biesterveld,
Ted Bambakidis,
Aaron M. Williams,
Rebecca Tagett,
Craig Johnson,
Martin Sillesen,
Baoling Liu,
Yongqing Li,
Hasan B. Alam
Publication year - 2020
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001605
Subject(s) - transcriptome , traumatic brain injury , microarray analysis techniques , downregulation and upregulation , biology , histone deacetylase inhibitor , neuroprotection , histone deacetylase , microarray , cancer research , microbiology and biotechnology , gene expression , gene , medicine , histone , pharmacology , biochemistry , psychiatry
We previously showed that the addition of valproic acid (VPA), a histone deacetylase inhibitor, to fresh frozen plasma (FFP) resuscitation attenuates brain lesion size and swelling following traumatic brain injury (TBI) and hemorrhagic shock (HS). The goal of this study was to use computational biology tools to investigate the effects of FFP+VPA on the brain transcriptome following TBI+HS.