Open AccessResuscitation From Hemorrhagic Shock With Fresh and Stored Blood and Polymerized Hemoglobin
Author(s) -
Alexander T. Williams,
Alfredo Lucas,
Cynthia R. Muller,
Carlos Muñoz,
Crystal BoldenRush,
Andre F. Palmer,
Pedro Cabrales
Publication year - 2020
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001530
Subject(s) - hemorrhagic shock , resuscitation , shock (circulatory) , hemoglobin , medicine , anesthesia
Hemoglobin (Hb)-based oxygen carriers (HBOCs) have been proposed as alternatives to blood for decades. Previous studies demonstrated that large molecular diameter HBOCs based on polymerized bovine Hb (PolybHb) attenuate Hb side-effects and toxicity. The objective of this study was to test the safety and efficacy of tense state PolybHb after long-term storage.