Open AccessHydrogen Gas Inhalation Attenuates Endothelial Glycocalyx Damage and Stabilizes Hemodynamics in a Rat Hemorrhagic Shock Model
Author(s) -
Tomoyoshi Tamura,
Motoaki Sano,
Tadashi Matsuoka,
Joe Yoshizawa,
Ryo Yamamoto,
Yoshinori Katsumata,
Jin Endo,
Koichiro Homma,
Mayumi Kajimura,
Mitsuaki Suzuki,
Eiji Kobayashi,
Junichi Sasaki
Publication year - 2019
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001459
Subject(s) - resuscitation , glycocalyx , hemodynamics , tumor necrosis factor alpha , medicine , pharmacology , oxidative stress , shock (circulatory) , chemistry , immunology , anesthesia
Hydrogen gas (H2) inhalation during hemorrhage stabilizes post-resuscitation hemodynamics, improving short-term survival in a rat hemorrhagic shock and resuscitation (HS/R) model. However, the underlying molecular mechanism of H2 in HS/R is unclear. Endothelial glycocalyx (EG) damage causes hemodynamic failure associated with HS/R. In this study, we tested the hypothesis that H2 alleviates oxidative stress by suppressing xanthine oxidoreductase (XOR) and/or preventing tumor necrosis factor-alfa (TNF-α)-mediated syndecan-1 shedding during EG damage.