Open AccessNeonatal Sepsis Alters the Excitability of Regular Spiking Cells in the Nucleus of the Solitary Tract in Rats
Author(s) -
Golnar Eftekhari,
Amir Shojaei,
Mohammad Reza Raoufy,
Hossein Azizi,
Saeed Semnanian,
Ali R. Mani
Publication year - 2019
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001453
Subject(s) - sepsis , electrophysiology , depolarization , solitary tract , medicine , excitatory postsynaptic potential , autonomic nervous system , membrane potential , anesthesia , hyperpolarization (physics) , heart rate , endocrinology , cardiology , biology , neuroscience , central nervous system , chemistry , receptor , blood pressure , organic chemistry , nuclear magnetic resonance spectroscopy
Sepsis is a leading cause of mortality and morbidity in infants. Although the measures of autonomic dysfunction (e.g., reduced heart rate variability) predict mortality in sepsis, the mechanism of sepsis-induced autonomic dysfunction has remained elusive. The nucleus of the solitary tract (NTS) is a vital structure for the integrated autonomic response to physiological challenges. In the present study we hypothesized that sepsis alters the excitability of NTS neurons in a rat model of neonatal sepsis (14-day-old rats).