Open AccessSIRT1 Mediates Septic Cardiomyopathy in a Murine Model of Polymicrobial Sepsis
Author(s) -
Lane M. Smith,
Barbara K. Yoza,
J. Jason Hoth,
Charles E. McCall,
Vidula Vachharajani
Publication year - 2019
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001429
Subject(s) - sepsis , lipopolysaccharide , medicine , inflammation , downregulation and upregulation , systemic inflammation , organ dysfunction , ex vivo , sirtuin 1 , septic shock , immunology , endocrinology , biology , in vitro , biochemistry , gene
Cardiac dysfunction, a common complication from severe sepsis, is associated with increased morbidity and mortality. However, the molecular mechanisms of septic cardiac dysfunction are poorly understood. SIRT1, a member of the sirtuin family of NAD+-dependent protein deacetylases, is an important immunometabolic regulator of sepsis, and sustained SIRT1 elevation is associated with worse outcomes and organ dysfunction in severe sepsis. Herein, we explore the role of SIRT1 in septic cardiac dysfunction using a murine model of sepsis.